SGLT-2 Inhibitors: A Novel Mechanism in Targeting Glycemic Control in Type 2 Diabetes Mellitus

OBJECTIVE: To review the chemistry, pharmacology, pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, dosing, drug interactions, and administration of canagliflozin, dapagliflozin, and empagliflozin, and comparing the benefit and risk aspects of using these agents in the older adult diabetes patient population. DATA SOURCES, STUDY SELECTION, DATA EXTRACTION, AND DATA SYNTHESIS: A search of PubMed using the terms SGLT-2 inhibitors, canagliflozin, dapagliflozin, empagliflozin, efficacy, and tolerability was performed to find relevant primary literature on each of the sodium/glucose cotransporter 2 (SGLT-2) inhibitors currently approved for use in type 2 diabetes. Phase III trials for all agents were included. All English-language articles from 2010 to 2015 appearing in these searches were reviewed for relevance to this paper. In addition, related articles suggested in the PubMed search were also reviewed. The SGLT-2 inhibitors have shown a reduction in hemoglobin A1c values and fasting plasma glucose levels with a low incidence of hypoglycemia. The incidence of mycotic infections is increased in patients taking an SGLT-2 inhibitor. CONCLUSION: SGLT-2 inhibitors may be a viable treatment option for patients not controlled on other oral agents. The risk of hypoglycemia is small. However, the clinical efficacy and tolerability of these agents has not been fully elucidated in older and frail patients

Optical control of internal electric fields in band-gap graded InGaN nanowires

InGaN nanowires are suitable building blocks for many future optoelectronic devices. We show that a linear grading of the indium content along the nanowire axis from GaN to InN introduces an internal electric field evoking a photocurrent. Consistent with quantitative band structure simulations we observe a sign change in the measured photocurrent as a function of photon flux. This negative differential photocurrent opens the path to a new type of nanowire-based photodetector. We demonstrate that the photocurrent response of the nanowires is as fast as 1.5 ps

A scalable framework for cross-lingual authorship identification

This is an accepted manuscript of an article published by Elsevier in Information Sciences on 10/07/2018, available online: https://doi.org/10.1016/j.ins.2018.07.009 The accepted version of the publication may differ from the final published version.© 2018 Elsevier Inc. Cross-lingual authorship identification aims at finding the author of an anonymous document written in one language by using labeled documents written in other languages. The main challenge of cross-lingual authorship identification is that the stylistic markers (features) used in one language may not be applicable to other languages in the corpus. Existing methods overcome this challenge by using external resources such as machine translation and part-of-speech tagging. However, such solutions are not applicable to languages with poor external resources (known as low resource languages). They also fail to scale as the number of candidate authors and/or the number of languages in the corpus increases. In this investigation, we analyze different types of stylometric features and identify 10 high-performance language-independent features for cross-lingual stylometric analysis tasks. Based on these stylometric features, we propose a cross-lingual authorship identification solution that can accurately handle a large number of authors. Specifically, we partition the documents into fragments where each fragment is further decomposed into fixed size chunks. Using a multilingual corpus of 400 authors with 825 documents written in 6 different languages, we show that our method can achieve an accuracy level of 96.66%. Our solution also outperforms the best existing solution that does not rely on external resources.Published versio

StyloThai: A scalable framework for stylometric authorship identification of Thai documents

This is an accepted manuscript of an article published by ACM in ACM Transactions on Asian and Low-Resource Language Information Processing in January 2020, available online: https://doi.org/10.1145/3365832 The accepted version of the publication may differ from the final published version.© 2020 Association for Computing Machinery. All rights reserved. Authorship identification helps to identify the true author of a given anonymous document from a set of candidate authors. The applications of this task can be found in several domains, such as law enforcement agencies and information retrieval. These application domains are not limited to a specific language, community, or ethnicity. However, most of the existing solutions are designed for English, and a little attention has been paid to Thai. These existing solutions are not directly applicable to Thai due to the linguistic differences between these two languages. Moreover, the existing solution designed for Thai is unable to (i) handle outliers in the dataset, (ii) scale when the size of the candidate authors set increases, and (iii) perform well when the number of writing samples for each candidate author is low.We identify a stylometric feature space for the Thai authorship identification task. Based on our feature space, we present an authorship identification solution that uses the probabilistic k nearest neighbors classifier by transforming each document into a collection of point sets. Specifically, this document transformation allows us to (i) use set distance measures associated with an outlier handling mechanism, (ii) capture stylistic variations within a document, and (iii) produce multiple predictions for a query document. We create a new Thai authorship identification corpus containing 547 documents from 200 authors, which is significantly larger than the corpus used by the existing study (an increase of 32 folds in terms of the number of candidate authors). The experimental results show that our solution can overcome the limitations of the existing solution and outperforms all competitors with an accuracy level of 91.02%. Moreover, we investigate the effectiveness of each stylometric features category with the help of an ablation study. We found that combining all categories of the stylometric features outperforms the other combinations. Finally, we cross compare the feature spaces and classification methods of all solutions. We found that (i) our solution can scale as the number of candidate authors increases, (ii) our method outperforms all the competitors, and (iii) our feature space provides better performance than the feature space used by the existing study.The research was partially supported by the Digital Economy Promotion Agency (project# MP-62- 0003); and Thailand Research Fund and Office of the Higher Education Commission (MRG6180266).Published versio

Physical and digital phantoms for validating tractography and assessing artifacts

Fiber tractography is widely used to non-invasively map white-matter bundles in vivo using diffusion-weighted magnetic resonance imaging (dMRI). As it is the case for all scientific methods, proper validation is a key prerequisite for the successful application of fiber tractography, be it in the area of basic neuroscience or in a clinical setting. It is well-known that the indirect estimation of the fiber tracts from the local diffusion signal is highly ambiguous and extremely challenging. Furthermore, the validation of fiber tractography methods is hampered by the lack of a real ground truth, which is caused by the extremely complex brain microstructure that is not directly observable non-invasively and that is the basis of the huge network of long-range fiber connections in the brain that are the actual target of fiber tractography methods. As a substitute for in vivo data with a real ground truth that could be used for validation, a widely and successfully employed approach is the use of synthetic phantoms. In this work, we are providing an overview of the state-of-the-art in the area of physical and digital phantoms, answering the following guiding questions: “What are dMRI phantoms and what are they good for?”, “What would the ideal phantom for validation fiber tractography look like?” and “What phantoms, phantom datasets and tools used for their creation are available to the research community?”. We will further discuss the limitations and opportunities that come with the use of dMRI phantoms, and what future direction this field of research might take

Native language identification of fluent and advanced non-native writers

This is an accepted manuscript of an article published by ACM in ACM Transactions on Asian and Low-Resource Language Information Processing in April 2020, available online: https://doi.org/10.1145/3383202 The accepted version of the publication may differ from the final published version.Native Language Identification (NLI) aims at identifying the native languages of authors by analyzing their text samples written in a non-native language. Most existing studies investigate this task for educational applications such as second language acquisition and require the learner corpora. This article performs NLI in a challenging context of the user-generated-content (UGC) where authors are fluent and advanced non-native speakers of a second language. Existing NLI studies with UGC (i) rely on the content-specific/social-network features and may not be generalizable to other domains and datasets, (ii) are unable to capture the variations of the language-usage-patterns within a text sample, and (iii) are not associated with any outlier handling mechanism. Moreover, since there is a sizable number of people who have acquired non-English second languages due to the economic and immigration policies, there is a need to gauge the applicability of NLI with UGC to other languages. Unlike existing solutions, we define a topic-independent feature space, which makes our solution generalizable to other domains and datasets. Based on our feature space, we present a solution that mitigates the effect of outliers in the data and helps capture the variations of the language-usage-patterns within a text sample. Specifically, we represent each text sample as a point set and identify the top-k stylistically similar text samples (SSTs) from the corpus. We then apply the probabilistic k nearest neighbors’ classifier on the identified top-k SSTs to predict the native languages of the authors. To conduct experiments, we create three new corpora where each corpus is written in a different language, namely, English, French, and German. Our experimental studies show that our solution outperforms competitive methods and reports more than 80% accuracy across languages.Research funded by Higher Education Commission, and Grants for Development of New Faculty Staff at Chulalongkorn University | Digital Economy Promotion Agency (# MP-62-0003) | Thailand Research Funds (MRG6180266 and MRG6280175).Published versio

CAG : stylometric authorship attribution of multi-author documents using a co-authorship graph

© 2020 The Authors. Published by IEEE. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://ieeexplore.ieee.org/document/8962080Stylometry has been successfully applied to perform authorship identification of single-author documents (AISD). The AISD task is concerned with identifying the original author of an anonymous document from a group of candidate authors. However, AISD techniques are not applicable to the authorship identification of multi-author documents (AIMD). Unlike AISD, where each document is written by one single author, AIMD focuses on handling multi-author documents. Due to the combinatoric nature of documents, AIMD lacks the ground truth information - that is, information on writing and non-writing authors in a multi-author document - which makes this problem more challenging to solve. Previous AIMD solutions have a number of limitations: (i) the best stylometry-based AIMD solution has a low accuracy, less than 30%; (ii) increasing the number of co-authors of papers adversely affects the performance of AIMD solutions; and (iii) AIMD solutions were not designed to handle the non-writing authors (NWAs). However, NWAs exist in real-world cases - that is, there are papers for which not every co-author listed has contributed as a writer. This paper proposes an AIMD framework called the Co-Authorship Graph that can be used to (i) capture the stylistic information of each author in a corpus of multi-author documents and (ii) make a multi-label prediction for a multi-author query document. We conducted extensive experimental studies on one synthetic and three real-world corpora. Experimental results show that our proposed framework (i) significantly outperformed competitive techniques; (ii) can effectively handle a larger number of co-authors in comparison with competitive techniques; and (iii) can effectively handle NWAs in multi-author documents.This work was supported in part by the Digital Economy Promotion Agency under Project MP-62-0003, and in part by the Thailand Research Fund and Office of the Higher Education Commission under Grant MRG6180266.Published versio

Young Muslim women's experiences of Islam and physical education in Greece and Britain: a comparative study

Previous research suggests that Muslim women can experience particular problems when taking physical education (PE) lessons, for example with dress codes, mixed-teaching and exercise during Ramadan; and they can face restrictions in extra-curricular activities for cultural and religious reasons. The area is under-researched and there is little evidence of comparative studies that explore similarities and differences in cross-national experiences, which is the aim of this paper. Two studies conducted in Greece and Britain that explored the views of Muslim women on school experiences of physical education are compared. Both studies focused on diaspora communities, Greek Turkish girls and British Asian women, living in predominantly non-Muslim countries. Growing concerns about global divisions between 'Muslims and the West' make this a particularly pertinent study. Qualitative data were collected by interviews with 24 Greek Muslim women, and 20 British Muslim women. \ud <P> \ud Physical education has national curriculum status and a similar rationale in both countries but with different cultures of formality and tradition, which impacted on pupils' experiences. Data suggested that Greek and British groups held positive views towards physical education but were restricted on their participation in extra-curricular activities. For the British women religious identity and consciousness of Islamic requirements were more evident than for the Greek women. Differences in stages of acculturation, historical and socio-cultural contexts contributed to less problematic encounters with physical education for Greek Muslims who appeared more closely assimilated into the dominant culture

HCV genotype-specific correlation with serum markers: Higher predictability for genotype 4a

Several factors have been proposed to assess the clinical outcome of HCV infection. The correlation of HCV genotypes to possible serum markers in clinical prediction is still controversial. The main objective of this study was to determine the existence of any correlation between HCV genotypes to viral load and different clinical serum markers.We performed a prospective cross-sectional and observational study. About 3160 serum HCV RNA positive patients were chosen from 4020 randomly selected anti-HCV positive patients. Statistical analysis was performed using the SPSS 16 software package. ROC (receiver operating characteristics) curves were used to compare diagnostic values of serum markers to predict genotypes.The most prevalent genotype was 3a (73.9%) followed by 1a (10.7%), 4a (6.4%) and 3b (6.1%) in Pakistani population. No correlation was found between viral load and serum markers for genotype 3a in a large no. of sample (n = 2336). While significant correlation was observed between viral load and AST in genotype 3b, ALP with viral load and ALT for genotype 1a. Patients with genotype 4a showed a significant inverse correlation with viral load and Hb level and AST with ALP. For genotype 4a, AUC (area under the curve) of ALT, ALP, AST, bilirubin, Hb level and viral load was 0.790, 0.763, 0.454, 0.664, 0.458 and 0.872 respectively.In conclusion, there was a significant variable response of HCV genotypes with serum markers. Severity of disease is independent of serum marker level in genotype 3a, while the liver damage in genotype 4a may associate with viral cytopathic effect as well as the immune-mediated process. An index using six serum markers may correctly predict genotype 4a in patients with ≥ 75% accuracy